Obviously, this would depend on what the person preferred to be involved with.  But, when it comes to prescription medication/opioids, probably some of the more commonly abused ones would be Vicodin, for example.  Vicodin is a drug that's commonly prescribed when people get injuries and suffer from pain over a decent period. People will start to take the Vicodin medication a lot of times and become addicted.

Initially, these drugs can induce a sense of euphoria, offering a much-needed respite from pain. This initial allure is particularly significant for individuals grappling with chronic pain and who are at risk of falling into the trap of opioid addiction.  For instance, Vicodin or Hydrocodone can be misused, with individuals seeking multiple prescriptions or turning to the illicit market.

Vicodin, Oxycodone, OxyContin

Another commonly abused opioid or prescription medication is Oxycodone or OxyContin.  This drug is again used for pain, and it's something that is well-known to be abused and is well-known to have addictive characteristics. It's one of the drugs that I see a lot being sold on the black market.

People will buy it and sell it to others.  They even make a business out of it.  Once you get addicted, it's very hard to become un-addicted to this particular drug.

In addition to OxyContin, I think probably the most addictive drug is heroin.  It's highly addictive, and it is highly degrading to the human body and the human spirit.  Heroin is probably one of the worst drugs that an individual could be addicted to.  It's very expensive.

You don't need as much of it to achieve a high and the desired effect that people are looking for.  People are consuming it in various ways.

Methamphetamine

Another, and perhaps one of the most commonly addictive opioids or drugs, is methamphetamine.  It ensnares people in addiction, leading to the destruction of their lives, bodies, minds, teeth, and health.  Methamphetamine is a highly addictive drug that traps individuals in a cycle from which they find it nearly impossible to break free.

So, there's a whole slew of different drugs, and I think it just depends on the person — how their body reacts to a particular opioid or drug, and that's why there are so many different things that can be used to help or cure people from drug addiction.

However, the most significant factor in the successful recovery of an addict who continues to abuse drugs is their will.  While there are numerous interventions available to help those struggling with opioid/drug abuse, the individual's desire to lead a clean and sober life is paramount. This personal willpower can be a beacon of hope in the journey towards recovery.